La llegada de Cal Crutchlow y Karel Abraham y el retorno de Toni Elías son las novedades en la lista de participantes de la campaña 2011. El grupo de la categoría reina está encabezado por el Campeón del Mundo Jorge Lorenzo, que lucirá el dorsal número 1 en su Yamaha.
No hay nuevos inscriptos en MOTO2 y muchos mas pilotos en 125 c.c.
Listas provisionales de inscritos Mundial 2011:
MotoGP
| 1 | Jorge Lorenzo | Yamaha Factory Racing | Yamaha |
| 5 | Colin Edwards | Monster Yamaha Tech3 | Yamaha |
| 4 | Andrea Dovizioso | Repsol Honda Team | Honda |
| 7 | Hiroshi Aoyama | San Carlo Honda Gresini | Honda |
| 8 | Héctor Barberá | Aspar Team | Ducati |
| 11 | Ben Spies | Yamaha Factory Racing | Yamaha |
| 14 | Randy de Puniet | Pramac Racing Team | Ducati |
| 17 | Karel Abraham | Cardion AB Motoracing | Ducati |
| 19 | Álvaro Bautista | Rizla SuzukiMotoGP | Suzuki |
| 24 | Toni Elías | LCR Honda MotoGP | Honda |
| 26 | Dani Pedrosa | Repsol Honda Team | Honda |
| 27 | Casey Stoner | Repsol Honda Team | Honda |
| 35 | Cal Crutchlow | Monster Yamaha Tech3 | Yamaha |
| 46 | Valentino Rossi | Ducati Team | Ducati |
| 58 | Marco Simoncelli | San Carlo Honda Gresini | Honda |
| 65 | Loris Capirossi | Pramac Racing Team | Ducati |
| 69 | Nicky Hayden | Ducati Team | Ducati |
Moto2
| 3 | Simone Corsi | Iodaracing Racing Project | Ioda |
| 4 | Randy Krummenacher | GP Team Switerland Kiefer Racing | Kalex |
| 9 | Kenny Noyes | Avintia-STX | FTR |
| 10 | Fonsi Nieto | G22 Racing Team | Moriwaki |
| 12 | Thomas Luthi | Interwetten Paddock M2 Racing | Suter |
| 13 | Anthony West | MZ Racing Team | MZ-RE Honda |
| 14 | Ratthapark Wilairot | Stop and Go Team | FTR |
| 15 | Alex de Angelis | JIR Moto2 | Motobi |
| 16 | Jules Cluzel | Forward Racing | Suter |
| 21 | Javier Forés | Mapfre Aspar Team | Suter |
| 25 | Alex Baldolini | Forward Racing | Suter |
| 29 | Andrea Iannone | Speed Master | Suter |
| 34 | Tito Rabat | BlusensSTX | FTR |
| 35 | Raffaele de Rosa | G22 Racing Team | Moriwaki |
| 36 | Mika Kallio | Marc VDS Racing Team | Suter |
| 38 | Bradley Smith | Tech3 Racing | Tech3 |
| 39 | Robertino Pietri | Italtrans Racing Team | Suter |
| 40 | Aleix Espargaró | Pons Racing | Pons-Kalex |
| 44 | Pol Espargaró | HP Tuenti Speep Up | Speep Up |
| 45 | Scott Redding | Marc VDS Racing Team | Suter |
| 49 | Kev Coghlan | Motorsport 69 | FTR |
| 51 | Michele Pirro | Gresini Racing Moto2 | Moriwaki |
| 53 | Valetin Debise | HP Tuenti Speep Up | Speep Up |
| 54 | Kenan Sofuoglu | Technomag CIP | Suter |
| 60 | Julito Simón | Mapfre Aspar Team | Suter |
| 63 | Mike Di Meglio | Tech3 Racing | Tech3 |
| 64 | Santiago Hernández | Sot and Go | FTR |
| 65 | Stefan Bradl | Viessman Kiefer Racing | Kalex |
| 68 | Yonny Hernández | Blusens-STX | FTR |
| 71 | Claudio Corti | Italtrans Racing Team | Suter |
| 72 | Yuki Takahashi | Gresini Racing Moto2 | Moriwaki |
| 75 | Mattia Pasini | Ioda Racing Project | Ioda |
| 76 | Max Neukirchner | MZ Racing Team | MZ-RE Honda |
| 77 | Dominique Aegerter | Technomag CIP | Suter |
| 80 | Axel Pons | Pons Racing | Pons-Kalex |
| 88 | Ricky Cardús | QMMF Racing Team | Moriwaki |
| 93 | Marc Márquez | Team Catalunya Caixa Repsol | Suter |
| 95 | Mashel Al Naimi | QMMF Racing Team | Moriwaki |
125cc
| 3 | Luigi Morciano | Team Italia FMI | Aprilia |
| 5 | Johan Zarco | Ajo Motorsport | Derbi |
| 7 | Efrén Vázquez | Ajo Motorsport | Derbi |
| 11 | Sandro Cortese | Racing Team Germany | Pendiente |
| 12 | Daniel Kartheininger | Caretta Technology Race Dept. | KTM |
| 15 | Simone Groztkyj | Worldwide Race | Aprilia |
| 17 | Taylor Mackenzie | Worldwide Race | Aprilia |
| 18 | Nico Terol | Bancaja Aspar Team | Aprilia |
| 19 | Alessandro Tonucci | Team Italia FMI | Aprilia |
| 21 | Harry Stafford | Ongetta-Centro Seta | Aprilia |
| 23 | Alberto Moncayo | Team Andalucía Cajasol | Aprilia |
| 25 | Maverick Viñales | PEV-Blusens-SMX-Paris Hilton | Aprilia |
| 26 | Adrián Martín | Motorsport 69 | Aprilia |
| 30 | Giulian Pedone | Worldwide Race | Aprilia |
| 31 | Niklas Ajo | TT Motion Events Racing | Aprilia |
| 39 | Luis Salom | Molenaar Racing GP | Aprilia |
| 40 | Sergio Gadea | PEV-Blusens-SMX-Paris Hilton | Aprilia |
| 43 | Francesco Muriello | WTR-Ten10 Racing | Aprilia |
| 44 | Miguel Oliveira | Team Andalucía Cajasol | Aprilia |
| 52 | Danny Kent | Red Bull Ajo Motorsport | Derbi |
| 53 | Jasper Iwema | Molenaar Racing GP | Aprilia |
| 55 | Héctor Faubel | Bancaja Aspar Team | Aprilia |
| 63 | Zulfahmi Khairuddin | Airasia-SIC-Ajo | Derbi |
| 69 | Sarath Kumar | WTR-Ten10 Racing | Aprilia |
| 71 | Tomoyoshi Koyama | Racing Tea Germany | Aprilia |
| 72 | Alexander Kristiansson | Matteoni Racing | Aprilia |
| 76 | Hiroki Ono | Caretta Technology Race Dept. | KTM |
| 77 | Marcel Schrötter | Mahindra Racing | Mahindra |
| 84 | Jakub Kornfeil | Ongetta-Centro Seta | Aprilia |
| 94 | Jonas Folger | Red Bull Ajo Motorsport | Derbi |
| 96 | Louis Rossi | Matteoni Racing | Aprilia |
| 99 | Danny Webb | Mahindra Racing | Mahindra |
